Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environmen...

Genetic Variants Associated with Colorectal Adenoma Susceptibility

BACKGROUND Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS We selected 1,326 patients with increased risk for advanced adeno...

Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

BACKGROUND Breast cancer today has many established risk factors, both genetic and environmental, but these risk factors by themselves explain only part of the total cancer incidence. We have investigated potential interactions between certain known genetic and phenotypic risk factors, specifically nine single nucleotide polymorphisms (SNPs) and height, body mass index (BMI) and hormone replace...

THE EFFECT OF BODY MASS INDEX ON COMPONENTS SIZE IN PATIENTS WITH KNEE REPLACEMENT SURGERY

This was Presented in 5th International Congress of Iranian Iranian Society of Knee Surgery, Arthroscopy, and Sports Traumatology (ISKAST), 14-17 Feb 2018- Kish, Iran

Association of Apolipoprotein E Polymorphism with Susceptibility to Multiple Sclerosis